Tumour necrosis factor-α gene haplotype is associated with pre-eclampsia
نویسندگان
چکیده
منابع مشابه
Tumor Necrosis Factor-α and Interleukin-1- β Polymorphisms in Pre-Eclampsia
Background: Pre-eclampsia is the most common critical condition during pregnancy. Plasma concentrations of tumor necrosis factor-alpha (TNF-α) and interleukin-1-beta (IL-1β) increase in pregnant women with pre-eclampsia, compared to normal pregnant women. Objective: To investigate the polymorphisms of IL-1β (C+3954T), TNF-α (G- 308A), and (G-238A) in preeclemptic women northeastern Iran. Me...
متن کاملSerum Tumor Necrosis Factor–α in Pre Eclampsia
Cy tok ines a re ma jo r con t r ibu to r s in pa thogenes i s o f p re eclampsia. Serum TNF-α was determined in 10 normal and 30 pre-eclamptic pregnant females with special reference to maternal age, parity and levels of mean ar ter ia l b lood pressure . TNF-α was determined us ing sandwich ELISA techn ique . Se rum TNF-α l eve l in normal p regnan t f emales was 9 .3 ± 0 .56 pg /ml , whi le ...
متن کاملPolymorphisms in the tumor necrosis factor-alpha gene in Turkish women with pre-eclampsia and eclampsia.
The genetic background predisposing pregnant women to pre-eclampsia/eclampsia (PE/E) is still unknown. The aim of the current study was to investigate whether there is an association between the TNF-alpha-308 and 850 polymorphisms and PE or eclampsia. In this study, 40 cases of eclampsia, 113 cases of PE and 80 normotensive control cases were genotyped for the TNF-alpha-G-308A and C-850 polymor...
متن کاملTumour Necrosis Factor-α Gene Polymorphism Is Associated with Metastasis in Patients with Triple Negative Breast Cancer
Tumour necrosis factor-α (TNF-α) is critical in the regulation of inflammation and tumour progression. TNF-α-308G > A is associated with constitutively elevated TNF-α expression. The purpose of this study was to assess the association between TNF-α-308G > A and breast cancer (BC) risk by subtype and the connection between genotypes and clinical features of BC. A total of 768 patients and 565 co...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: MHR: Basic science of reproductive medicine
سال: 2005
ISSN: 1460-2407,1360-9947
DOI: 10.1093/molehr/gah182